Michael Maes Selected Research

Uric Acid (Urate)

10/2020	Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments.
10/2019	Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures.
10/2018	Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses.
8/2018	Metabolic syndrome and the decreased levels of uric acid by leflunomide favor redox imbalance in patients with rheumatoid arthritis.
11/2017	Indices of insulin resistance and glucotoxicity are not associated with bipolar disorder or major depressive disorder, but are differently associated with inflammatory, oxidative and nitrosative biomarkers.
4/2017	Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: Associations with inflammatory and oxidative stress biomarkers and uric acid.
3/2017	A model of the mitochondrial basis of bipolar disorder.
7/2015	Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder.

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Michael Maes Research Topics

Disease

74	Schizophrenia (Dementia Praecox) 05/2023 - 04/2002
70	Inflammation (Inflammations) 11/2023 - 09/2002
43	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) 04/2024 - 10/2005
41	Fatigue 11/2023 - 10/2006
34	Psychotic Disorders (Schizoaffective Disorder) 11/2023 - 01/2004
33	Major Depressive Disorder (Major Depressive Disorders) 02/2024 - 01/2014
33	Bipolar Disorder (Manic Depressive Psychosis) 10/2023 - 09/2002
31	Mood Disorders (Mood Disorder) 04/2023 - 11/2003
26	Depressive Disorder (Melancholia) 10/2022 - 02/2005
23	Infections 05/2023 - 10/2003
17	Cognitive Dysfunction 04/2024 - 02/2012
15	Medically Unexplained Symptoms 01/2023 - 02/2012
15	Mental Disorders (Mental Disorder) 11/2022 - 12/2002
14	COVID-19 02/2024 - 12/2020
14	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 12/2012
13	Insulin Resistance 04/2024 - 11/2014
13	Multiple Sclerosis 05/2020 - 01/2011
13	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 01/2011
12	Pain (Aches) 02/2024 - 10/2006
12	Fibromyalgia (Fibrositis) 01/2023 - 12/2013
12	Neoplasms (Cancer) 01/2023 - 02/2002
12	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2014
11	Autism Spectrum Disorder 03/2024 - 01/2018
11	Neuroinflammatory Diseases 01/2022 - 11/2012
10	Autistic Disorder (Autism) 01/2021 - 01/2002
10	Parkinson Disease (Parkinson's Disease) 01/2021 - 12/2013
9	Tobacco Use Disorder (Nicotine Dependence) 11/2021 - 06/2014
8	Post-Acute COVID-19 Syndrome 04/2024 - 01/2022
8	Obesity 02/2024 - 01/2011
8	Anxiety Disorders (Anxiety Disorder) 01/2024 - 12/2012
8	Necrosis 01/2021 - 12/2002
7	Stroke (Strokes) 01/2024 - 01/2011
7	Wounds and Injuries (Trauma) 01/2023 - 08/2010
6	Ischemic Stroke 01/2023 - 01/2019
6	Treatment-Resistant Depressive Disorder 04/2022 - 02/2004

Drug/Important Bio-Agent (IBA)

84	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2012
61	CytokinesIBA 03/2024 - 01/2002
60	Tryptophan (L-Tryptophan)FDA Link 11/2023 - 09/2002
40	Immunoglobulin M (IgM)IBA 04/2024 - 10/2003
40	AntioxidantsIBA 10/2023 - 10/2006
34	Immunoglobulin A (IgA)IBA 04/2024 - 04/2007
32	Proteins (Proteins, Gene)FDA Link 01/2024 - 06/2002
26	Antidepressive Agents (Antidepressants)IBA 04/2024 - 12/2002
22	Interleukin-6 (Interleukin 6)IBA 05/2023 - 12/2002
20	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2022 - 12/2002
19	InterleukinsIBA 11/2023 - 02/2005
19	ZincIBA 11/2023 - 12/2005
18	Interleukin-10 (Interleukin 10)IBA 01/2023 - 12/2002
17	Aryldialkylphosphatase (Paraoxonase)IBA 01/2023 - 04/2014
17	Malondialdehyde (Propanedial)IBA 01/2023 - 04/2011
16	C-Reactive ProteinIBA 04/2024 - 04/2011
15	LipidsIBA 01/2024 - 10/2006
15	CalciumIBA 11/2023 - 03/2017
15	KynurenineIBA 11/2023 - 09/2002
15	Serotonin (5 Hydroxytryptamine)IBA 01/2022 - 03/2005
13	Advanced Oxidation Protein Products (AOPP)IBA 04/2024 - 11/2017
11	EpitopesIBA 01/2024 - 02/2012
11	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023 - 02/2012
10	HDL CholesterolIBA 01/2024 - 04/2014
10	EnzymesIBA 10/2022 - 12/2007
10	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 08/2022 - 12/2005
10	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2022 - 04/2011
10	AntibodiesIBA 10/2019 - 03/2003
9	MagnesiumIBA 12/2022 - 12/2012
9	Fatty Acids (Saturated Fatty Acids)IBA 08/2022 - 05/2004
9	Polytetrafluoroethylene (Teflon)FDA Link 10/2021 - 10/2014
9	HaptoglobinsIBA 01/2021 - 03/2005
9	Glutathione (Reduced Glutathione)IBA 01/2021 - 04/2011
8	Immunoglobulin G (IgG)IBA 04/2024 - 03/2003
8	Interleukin-17 (Interleukin 17)IBA 01/2024 - 10/2015
8	ChemokinesIBA 01/2023 - 05/2018
8	AlbuminsIBA 01/2023 - 10/2016
8	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2023 - 04/2011
8	Opioid Analgesics (Opioids)IBA 12/2022 - 01/2019
8	InterferonsIBA 01/2022 - 02/2005
8	Antipsychotic Agents (Antipsychotics)IBA 10/2021 - 04/2002
8	Uric Acid (Urate)IBA 10/2020 - 07/2015
8	DNA (Deoxyribonucleic Acid)IBA 04/2019 - 01/2009
8	NeopterinIBA 12/2012 - 07/2003
7	Messenger RNA (mRNA)IBA 04/2024 - 05/2012
7	CholesterolIBA 01/2024 - 05/2004
7	LipopolysaccharidesIBA 01/2024 - 02/2004
7	oxidized low density lipoproteinIBA 11/2022 - 09/2010
7	Glucose (Dextrose)FDA LinkGeneric 11/2022 - 11/2014
7	HDL LipoproteinsIBA 01/2021 - 04/2014
7	MelatoninIBA 03/2017 - 06/2012
6	Hormones (Hormone)IBA 04/2024 - 10/2005
6	Minocycline (Cyclops)FDA LinkGeneric 02/2024 - 12/2014
6	Interleukin-1 (Interleukin 1)IBA 01/2024 - 02/2012
6	AntigensIBA 01/2024 - 01/2013
6	CateninsIBA 01/2024 - 08/2019
6	Methamphetamine (Desoxyn)FDA LinkGeneric 11/2023 - 01/2019
6	Peroxidase (Myeloperoxidase)IBA 05/2023 - 10/2020
6	Insulin (Novolin)FDA Link 05/2023 - 11/2014
6	Fluoxetine (Prozac)FDA LinkGeneric 01/2023 - 02/2004
6	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2023 - 01/2004
6	CopperIBA 01/2023 - 03/2021
6	HMGB1 Protein (HMG1)IBA 11/2022 - 10/2020
6	Brain-Derived Neurotrophic Factor (BDNF)IBA 08/2022 - 04/2011

Therapy/Procedure

12	Therapeutics 04/2022 - 01/2004